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Recurrence of Invasive Moles and Choriocarcinomas
Author(s) -
Hirokawa Kiyoji,
Tomoda Yutaka,
Kaseki Shigeaki,
Ishizuka Takao,
Nishikawa Yoshiki,
Goto Setsuko
Publication year - 1986
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1986.tb00154.x
Subject(s) - choriocarcinoma , regimen , medicine , complete remission , oncology , mole , gynecology , gastroenterology , chemotherapy
Prevention of the recurrence is the most important issue to be considered for improving the results of treatment of trophoblastic disease. The authors strictly differentiated choriocarcinoma and invasive mole and studied problems related to their recurrence. There were 17 recurrent cases out of 320 invasive moles treated until 1979. Among them histologically confirmed cases were all found to be choriocarcinoma at the time of recurrence. By applying strict criteria for judgement of complete remission, a drop of 7.7 — 1.8% in the recurrence rate was achieved. Regarding 159 choriocarcinoma cases treated until 1979, the remission rate was remarkably improved, but decrease in the recurrence rate could not be achieved. The risk factors involved in the recurrence of the disease were investigated, and factors such as history of hydatidiform mole, tumor localization, alteration of platelet count, and number of chemotherapeutic courses needed after hCG dropped to minimum level were found to be related. Since 1980, observance of the risk factors and improved treatment regimen has decreased the recurrence rate of choriocarcinoma.