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Changes in LHRH in Human Maternal Plasma during Pregnanc‐
Author(s) -
Kawamura asuhiro,
Miyake Akira,
Sakumoto Tetsuro,
Tasaka Keiichi,
Aono Toshihiro
Publication year - 1985
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1985.tb00767.x
Subject(s) - endocrinology , medicine , luteinizing hormone , human chorionic gonadotropin , hormone , plasma levels , gonadotropin , plasma concentration , biology
The changes in luteinizing hormone‐releasing hormone (LHRH) and human chorionic gonadotropin (hCG) concentrations in the maternal plasma during pregnanc‐ were determined b‐ radioimmunoassa‐. The mean (±SE) plasma levels of immunoreactive LHRH in all pregnant women (2.4±0.5 pg/ml) were significantl‐ lower than those in normal c‐cling women (4.2±0.3 pg/ml). When the mean levels were measured ever‐ 4 weeks, levels from the 8th to the 19th week and from the 32nd to the 41st week of pregnanc‐ were found to be significantl‐ lower than those in normal c‐cling women. However, the levels of LHRH at each stage of pregnanc‐ did not var‐ significantl‐ compared with the mean value of LHRH throughout the pregnanc‐. The mean hCG levels in the maternal plasma were highest from the 8th to the 11th week of pregnanc‐ and decreased graduall‐. These data suggest that: i) the plasma LHRH levels during pregnanc‐ are not related to those of hCG, ii) the LHRH secretion from maternal h‐pothalamus ma‐ be suppressed, and iii) LHRH s‐nthesized in the placenta ma‐ be degraded when it enters the maternal circulation