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Endometriosis and Various Pelvic Lesions Associated with H‐perprolactinemia
Author(s) -
Abe Jun,
Kimura Junji,
Hirose Toshiuki,
Tamaa Teruhiko,
Okada Hiroji
Publication year - 1985
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1985.tb00760.x
Subject(s) - endometriosis , medicine , bromocriptine , prolactin , galactorrhea , incidence (geometry) , hormone , immunohistochemistry , gynecology , gastroenterology , endocrinology , physics , optics
The serum prolactin (PRL) levels of 34 cases of endometriosis, 26 cases of adeno‐m‐osis, 30 cases of functional d‐smenorrhea, and 9 patients with m‐oma uteri were measured b‐ radioimmunoassa‐. The incidence of h‐perprolactinemia (>22 ng/ml) was 100, 38.0, 30.8, 40.0 and 44.4% in cases of Acosta's severe t‐pe, Beecham II and III groups, adenom‐osis, functional d‐smenorrhea, and m‐oma uteri, respectivel‐. The rate of galactorrhea was 19% of Acosta's severe cases, the highest among the five groups. The mean value of peripheral PRL in Acosta's severe t‐pe was significantl‐ higher than that of the other four groups. The immunohistochemical stud‐ on PRL localization demonstrated the positive reaction at the apical membrane of the glands in normal and ectopic endometria, suggesting PRL binding sites rather than production sites. The PRL levels of the operated group tended to decrease spontaneousl‐ after operation. Among the various hormone treatments, it was of interest that some cases improved s‐mptomaticall‐ and objectivel‐ after treatment with bromocriptine alone. Our stud‐ suggests that PRL, as one of hormonal factors, ma‐ pla‐ a role in the development of endometriosis.