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Suppressive Effect of Prostaglandin D 2 on Prolactin Secretion from Rat Anterior Pituitary
Author(s) -
Arisawa Masayoshi,
Makino Tsunehisa,
Izumi Sunichiro,
Lizuka Rihachi
Publication year - 1985
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1985.tb00058.x
Subject(s) - medicine , anterior pituitary , endocrinology , prolactin , ovariectomized rat , prolactin cell , secretion , prostaglandin , in vivo , estrogen , in vitro , chemistry , incubation , dose , biology , hormone , microbiology and biotechnology , biochemistry
Prostaglandin D 2 (PGD 2 ) was investigated for its effect on prolactin (PRL) secretion from rat anterior pituitary in vitro and in vivo. Significant suppression in the release of PRL was observed when the anterior pituitaries were incubated for 4 hours in vitro in the presence of more than 100 μg of PGD 2 /ml incubation medium. In the second experiment, animals received intravenous injections of PGD 2 after pretreatment of ovariectomized mature rats with estrogen and progesterone. Thirty minutes after injection of 250 μg or 500 μg of PGD 2 , serum PRL levels were significantly lower than levels before the PGD 2 injection. The injection of the vehicle control did not affect serum PRL levels. These results suggest that at high dosages PGD 2 suppresses PRL secretion by acting directly on the rat anterior pituitary gland.