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Clinical Significance of Antithrombin III, Plasminogen and Alpha 2 ‐plasmin Inhibitor in Perinatal Period
Author(s) -
Fuse Yoji,
Fuse Kozue
Publication year - 1985
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1985.tb00057.x
Subject(s) - antithrombin , plasmin , alpha (finance) , medicine , gestational age , endocrinology , pregnancy , chemistry , biology , biochemistry , heparin , surgery , enzyme , construct validity , genetics , patient satisfaction
We studied changes in antithrombin III, plasminogen and alpha 2 ‐plasmin inhibitor levels in the maternal and cord blood by a newly developed fluorescent substrate assay method. Correlations between bleeding on parturition and weight of the newborn were also studied. No marked changes in antighrombin III, plasminogen and alpha 2 ‐plasmin inhibitor levels were noted before or after parturition in either the normal bleeding or the abnormal bleeding group, but preparturient plasminogen and alpha 2 ‐plasmin inhibitor values correlated with amount of bleeding on parturition, and could therefore be used to predict intrapartal bleeding. The SGA (small for gestational age) group showed a significant decrease of plasminogen and alpha 2 ‐plasmin inhibitor compared with the AGA (appropriate for gestational age) and LGA (large for gestational age) group, which was understood to be due to mild acidosis caused by stress in pregnancy and on parturition and immaturity of the neonatal liver.