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Calmodulin in Breast Milk, and Umbilical and Maternal Plasma
Author(s) -
Hira Takaaki,
Fukumoto Seigo,
Kono Shinzo,
Takenaka Shizuhiro
Publication year - 1985
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1985.tb00055.x
Subject(s) - calmodulin , umbilical vein , umbilical cord , umbilical artery , radioimmunoassay , medicine , breast milk , endocrinology , lactation , calcium , gestation , pregnancy , fetus , chemistry , biology , immunology , biochemistry , in vitro , genetics
Calmodulin concentrations were determined by radioimmunoassay in breast milk and the plasmas of cord vessels and of nonpregnant and pregnant women. Calmodulin concentrations in the maternal plasma rose slightly in the 36–39th week of gestation, maintained a high level until the 5th postpartum day, and then decreased to nearly the non‐pregnant control level. Among intrapartum plasma samples calmodulin concentration increased in the order: umbilical vein, umbilical artery, maternal peripheral vein. The breast milk calmodulin concentrations on the 5th and 30th postpartum day were 8.7‐ and 10.5‐times higher respectively than those in the maternal plasma obtained simultaneously. The calmodulin concentrations in breast milk, and maternal and umbilical plasma were too low to bind all the calcium contained in these samples. These results suggest that calmodulin is also present in the human mammary gland and that it might play some role in modulating the calcium transport there.