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Danazol (an Antigonadotropin) in the Treatment of Catamenial Pneumothorax
Author(s) -
Uemura Tsuguo,
JVIatsuyama Akemi,
Minaguchi Hiroshi,
Ikeda Hirotada
Publication year - 1985
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1985.tb00051.x
Subject(s) - danazol , medicine , ovulation , menstruation , endometriosis , asymptomatic , pneumothorax , surgery , menstrual cycle , gynecology , hormone
Two cases of catamenial pneumothorax treated with danazol, an isoxazole derivative of 17α‐ethinyl testosterone, are reported. The first patient, a 44‐year‐old woman who had had 31 attacks of spontaneous pneumothorax at the onset of menstruation in the past 7 years, was given 400 mg danazol daily for 6 months. Episodes did not reoccur during the treatment or for 5 months after the treatment, though ovulation was observed in the first menstrual cycle after the treatment. The second patient was a 33‐year‐old woman who had had recurrent right‐sided chest pains related to the onset of menses. The endometrial implants in the diaphragm were excised but a right pneumothorax recurred at the first menstrual period after operation. After 4 months of therapy with danazol she has been asymptomatic for 20 months. Danazol therapy seems to be more effective on this disease and to have less side effects than other ovulation inhibiting drugs.