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Effect of γ‐Oryzanol on Serum Lipid Peroxide Level and Clinical Symptoms of Patients with Climacteric Disturbances
Author(s) -
Ishihara Minoru
Publication year - 1984
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1984.tb00693.x
Subject(s) - climacteric , lipid peroxide , triglyceride , hyperlipidemia , cholesterol , chemistry , medicine , ferulic acid , endocrinology , food science , antioxidant , biochemistry , lipid peroxidation , menopause , diabetes mellitus
The effect of γ‐Oryzanol, ferulic acid esters obtained from rice oil, on climacteric disturbances was studied with special reference to lipid peroxide levels in the sera of patient. 300 mg of γ‐Oryzanol was administered daily to each patient for 4 to 8 weeks. In 85% of 40 cases the effect on the climacteric disturbance was judged by the Kupperman method to be significant. In patients with climacteric disturbances, serum lipid peroxide levels were high, but were reduced significantly after administration of γ‐Oryzanol. By its administration, total cholesterol, triglyceride and HDL‐cholesterol were improved in cases with hyperlipidemia (TC<220 mg/dl, TG<140 mg/dl, HDL‐chol.>;45 mg/dl). The atherogenic index was also considerably reduced. No side effects and no particular changes in functional tests were observed.