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Biological Distribution of Oncofetal Antigen‐I (OFA‐I) in Gynecologic Tumors and Trophoblastic Tissues
Author(s) -
Higuchi Masaomi,
Takeuchi Shoshichi
Publication year - 1983
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1983.tb00659.x
Subject(s) - oncofetal antigen , antigen , choriocarcinoma , trophoblast , carcinoma , ovary , pathology , ovarian carcinoma , fetus , trophoblastic tumor , biology , cancer , ovarian cancer , medicine , placenta , immunology , tumor associated antigen , pregnancy , gestation , immunotherapy , genetics
Oncofetal Antigen‐I (OFA‐I) is a membrane antigen of human cancer cells that cross‐reacts with human fetal brain tissues. The presence of this antigen was examined in a variety of histological types of gynecologic tumors, trophoblasts and normal tissues. A total of 22 tumors, 13 trophoblasts and 48 normal tissues were tested by IA absorption using patient's sera containing functionally mono‐specific anti‐OFA‐I. Ovarian carcinoma had the highest percentage of reactivity to OFA‐I (78%) followed by cervical carcinoma (40%). Conversely, this antigen was not detected in endometrial carcinoma (0%), normal trophoblast tissue (0%) or hydatidiform mole (0%) or in normal tissues from non‐cancer patients. These studies show that OFA‐I is frequently detected in ovarian carcinomas.