Premium
Comparative Study of Prostaglandin I 2 and Prostaglandin E 2 on Hemodynamics in Pregnant Dogs
Author(s) -
Murayama Keisaburo,
Kasai Hiroshi,
Ouchi Hiroko
Publication year - 1983
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1983.tb00641.x
Subject(s) - prostaglandin e , concomitant , prostaglandin , blood pressure , medicine , hemodynamics , endocrinology , prostaglandin f , mean arterial pressure , chemistry , heart rate
Abstract Effects of intravenous injections of prostaglandin I 2 (PGI 2 ) and prostaglandin E 2 (PGE 2 ) on mean arterial pressure (MAP), cardiac output (CO), heart rate (HR), renal blood flow (RBF), and uterine blood flow (UBF) were investigated in the pregnant dog. A dose‐dependent fall in MAP was observed with PGI 2 and PGE 2 (PGI 2 >PGE 2 ). HR was almost unchanged by both prostaglandins. PGI 2 and PGE 2 produced increases in CO and RBF in a dose‐dependent manner (PGI 2 >PGE 2 ). PGI 2 caused a dose‐dependent decrease in UBF, while PGE 2 caused an increase in UBF during the period without concomitant increase in intrauterine pressure (IUP) and a decrease in UBF during the period with concomitant increase in IUP. The possibility of treatment of pregnancy‐induced hypertension with PGI 2 or PGE 2 is discussed.