Premium
The Effect of Maternal Glucose Administration upon Fetal Myocardial Glycogen Change During Acute Blood Loss in the Term Pregnant Dog
Author(s) -
Takeda Yoshihiko,
Hongo Motohiro,
Gabel Paul V.,
Romney Seymour L.
Publication year - 1983
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1983.tb00608.x
Subject(s) - glycogen , medicine , fetus , endocrinology , bradycardia , fetal distress , heart rate , pregnancy , biology , blood pressure , genetics
(1) To evaluate the effect of maternal glucose loading upon myocardial glycogen and cardiovascular function in induced fetal distress, acute maternal hemorrhage was caused in term pregnant dogs pretreated with 1.5 gm/Kg of glucose 15 minutes before initiating hemorrhage. (2) Myocardial glycogen depletion followed almost the same pattern as in the untreated group, reaching a level a little below half of the control at the end of the experiment. (3) Fetal heart rate changes were altered by glucose administration in two respects: prolonged initial techycardia and less severe progressive bradycardia when this occurred. (4) Other main effects of glucose during the hypotensive period were significantly higher increases in both fetal and maternal plasma glucose compared to the untreated group and a tremendous increase of fetal pCO 2 and decrease of fetal pH. (5) It may be concluded that glucose pretreatment is effective in providing oxidative energy to hypoxic cardiac muscle for its contractile activity.