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Transient Luteolytic Effect of Prostaglandin E 2 in Humans
Author(s) -
ElRahman Hany A,
ElSokkary Hassan A,
ElAbd Morad A,
Shaala Saied A,
Gaweesh Sherief S,
Toppozada Mokhtar K
Publication year - 1982
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1982.tb00594.x
Subject(s) - vomiting , medicine , erythema , prostaglandin e2 , abdominal pain , anesthesia , prostaglandin , surgery
Prostaglandin E 2 was administered by i.v. infusion to ten non pregnant volunteers at a constant dose rate of 4.5 μ g/min for 5.5 hours with a mean total dose of 1.5 mg. The infusion was accompanied by flushing, local pain, erythema, abdominal cramps and vomiting. The menstrual cycles were normal in every aspect except its earlier occurrence in some women. An acute drop in plasma progesterone occurred after half an hour in the majority of cases, but this decline was ransient, since most cases showed a clear post‐infusion recovery.