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Occurrences of Estrogen and Progestin Receptors and Nuclear Binding of Steroid‐ Receptor Complex in Human Endometrial Cancer
Author(s) -
Tamaya Teruhiko,
Tsurusaki Toshihide,
Kusanishi Hiroshi,
Yamada Toshio,
Wada Keisuke,
Fujimoto Jiro,
Okada Hiroji
Publication year - 1982
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1982.tb00592.x
Subject(s) - estrogen receptor , estrogen , cytosol , progestin , endometrial cancer , medicine , endocrinology , mechanism of action , receptor , steroid , estrogen receptor beta , nuclear receptor , chemistry , progesterone receptor , estrogen receptor alpha , steroid hormone , cancer research , hormone , cancer , biology , breast cancer , biochemistry , gene , transcription factor , in vitro , enzyme
Synopsis The relationship between the histological grade and the steroid action mechanism was investigated in human endometrial cancer. The concentration and detection rate of cytosol estrogen (ER) and progestin receptor (PR) tended to decrease, and the rate of detected both ER and PR decreased as the tumor progressed from well differentiated to poorly differentiated grades. It appears that the mechanism of action of estrogen is impaired in undifferentiated cancer. The total quantity and detection rate in the nuclear binding of estrogen‐ER complexes tended to increase and those of progestin‐PR complexes tended to decrease as the tumor grade advanced. One may speculate that estrogen is biologically effective due to the increased nuclear binding sites of estrogen‐ER complex instead of decreased cytosol receptor sites in undifferentiated tumors.