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Human Prolactin Receptor and Dopamine Actions in Feminizing Adrenal Neoplastic Cells
Author(s) -
Furuhashi Nobuaki,
Fang Victor S.
Publication year - 1981
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1981.tb00541.x
Subject(s) - phenoxybenzamine , endocrinology , medicine , dopaminergic , propranolol , dopamine , prolactin , pimozide , receptor , dopamine receptor , chemistry , adrenergic receptor , mechanism of action , biology , hormone , in vitro , haloperidol , biochemistry
Estrogen production by feminizing adrenal neoplastic cells (Fang‐8 cells) in culture was stimulated by human prolactin (hPRL). The existence of hPRL receptor in the cells was demonstrated. The stimulatory effect of hPRL was abolished by dopamine and CB‐154 (2‐bromo‐α‐ergocriptine), since CB‐154, at 60 μg/dish, inhibited cell growth and estrogen production in the absence of hPRL and since dopamine may involve different mechanisms of action. The action of CB‐154 was blocked by propranolol, not by phenoxybenzamine or pimozide. Since we could not demonstrate adrenergic or dopaminergic receptor in Fang‐8 cells, the interaction between CB‐154 and propranolol may not be explained by a pharmacological beta‐adrenergic mechanism.