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Estriol and the Kidney in Pregnancy
Author(s) -
Honjo Hideo,
Omori Kenji,
Yamamoto Takao,
Otsubo Kazuo,
Sakai Chiaki,
Tsukamoto Katsumi,
Yasuda Jinsuke,
Fujii Masahiro,
Yamaki Junko,
Okada Hiroji,
Numazawa Mitsuteru,
Nambara Toshio
Publication year - 1981
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1981.tb00540.x
Subject(s) - estriol , urinary system , pregnancy , creatinine , radioimmunoassay , urine , endocrinology , kidney , medicine , chemistry , hormone , biology , genetics
Estriol‐16α‐glucosiduronate in the urine and serum of pregnant women was measured by a direct radioimmunoassay which was highly specific for this compound and did not require hydrolysis or chromatography. Urinary and serum estriol‐16α‐glucosiduronate increased as pregnancy progressed. Pregnant women with presumptive renal failure (toxemia of pregnancy, malignant hypertension, post renal transplantation, etc) showed low urinary levels of estriol‐16α‐glucosiduronate but normal serum levels. Their renal clearance of estriol‐16α‐glucosiduronate was calculated provisionally and compared to that of creatinine. The results suggest that some serum estriol is conjugated by the kidney and that the measurement of estriol‐16α‐glucosiduronate can be used as a clinical index of renal failure during pregnancy.