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Properties of Strain Cells of the Uterine Invasive Mole and of Its Metastatic Choriocarcinomas
Author(s) -
Nakamoto Osamu
Publication year - 1980
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1980.tb00508.x
Subject(s) - cytotrophoblast , syncytiotrophoblast , mole , strain (injury) , endocrinology , biology , chemistry , choriocarcinoma , medicine , pathology , fetus , placenta , genetics , pregnancy
No report could be found concerning the strain cells of the invasive mole. We could establish the three strain cells from materials which were histologically diagnosed as invasive mole. At the same time, five strain cells were obtained from a cerebral metastatic choriocarcinoma focus. The present work was designed to elucidate the nature and genesis of this mole by repeating the analysis on the cell level. Phase contrast microscopy revealed two types of proliferation, one was single‐layered and the other multi‐layered. In the latter, the cells were piled up one on another resembling cancer cells. Electron microscopic observation revealed there were two kinds of cells, one having papillary processes grown on the free surface and designated as syncytiotrophoblast, the other type resembled a cytotrophoblast. The growth curve was established and doubling time based on it was calculated as 2.2 days. The chromosome count, fell in the higher polyploid zone. Both strains produced glycoprotein hormones (hCG, ACTH), and steroid hormones (progesterone, estrogen) in large amounts. Both series of strain had many similarities and a few differences suggesting the possibility that cancerous cells may be mingled in some invasive moles under pathological conditions.