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Genetic Amniocentesis and Follow‐Up Study of the Infants: A Japanese Collaborative Work
Author(s) -
Sugawa Tadashi,
Ogita Sachio,
Matsumoto Masahiko,
Yagami Yoshiaki,
Suzumori Kaoru,
Kitagawa Teruo,
Tada Keiya,
Jinbo Toshiharu
Publication year - 1980
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1980.tb00498.x
Subject(s) - amniocentesis , medicine , obstetrics , second trimester , fetus , pregnancy , prenatal diagnosis , perinatal mortality , triple test , advanced maternal age , pediatrics , genetics , biology
Prenatal diagnosis of genetic disease in Japan today, as of the end of 1978, and results of a follow‐up study of infants born after genetic amniocentesis are reported. Of the 585 amniocentesis in 523 women, 568 cases contributed data for the results of their analysis. A previous history of pregnancy with Down's syndrome was a major indication in these 585 cases (59.5%); other indications included advanced maternal age 69 cases (11.8%), and metabolic disorder 56 cases (9.6%). Fetal loss occurred in a total 12 out of 542 cases (2.2%). Ten of these fetal losses occurred during the mid‐trimester. No increase in perinatal mortality, perinatal morbidity or retardation of physical and mental development as a consequence of amniocentesis was observed. Erroneous diagnosis was attested in 7 out of 568 cases (1.2%). Test accuracy was thus demonstrated at 98.8%.