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Metabolic Effects of Contraceptive Steroids III. Intravenous Glucose Tolerance — Short Term Observations
Author(s) -
Mangat H.K.,
Chaudhury R.R.,
Devi P.K.
Publication year - 1972
Publication title -
the journal of the asian federation of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0377-0532
DOI - 10.1111/j.1447-0756.1972.tb00323.x
Subject(s) - megestrol acetate , mestranol , medicine , lynestrenol , progestogen , endocrinology , estrogen , glucose tolerance test , population , diabetes mellitus , family planning , research methodology , insulin resistance , environmental health , cancer
Intravenous glucose tolerance tests were carried out in women taking two types of oestrogen‐progestogen combination oral contraceptives. Each subject had the test done on day 18‐21 in a control cycle before the medication was started and three consecutive cycles during administration of the drug. Fasting blood glucose levels and K values showed no significant changes with combination of megesterol acetate (4 mgm.) with 0.05 mgm. of ethinyl oestradiol. A significant decline in glucose tolerance was observed by the change in K values during all the three cycles of medication with combination of Lynestrenol 2.5 mgms. with 0.075 mgm. of mestranol. Tests repeated after 2 months after stoppage of medication in five subjects showed that blood sugar levels and K values had returned to pretreatment levels .