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Effect of vitamin D on insulin sensitivity in elderly patients with impaired fasting glucose
Author(s) -
Naharci Ilkin,
Bozoglu Ergun,
Kocak Necmettin,
Doganci Suat,
Doruk Huseyin,
Serdar Muhittin
Publication year - 2012
Publication title -
geriatrics and gerontology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 57
eISSN - 1447-0594
pISSN - 1444-1586
DOI - 10.1111/j.1447-0594.2011.00791.x
Subject(s) - medicine , endocrinology , insulin resistance , insulin , vitamin , insulin sensitivity , vitamin d and neurology , body mass index , homeostasis , glucose homeostasis
Aim: Recent data has shown that vitamin D increases insulin sensitivity; however, there is little evidence about the effects of this treatment on elderly people with impaired fasting glucose. The aim of the present study was to investigate the effect of vitamin D treatment on insulin sensitivity and metabolic parameters in elderly people with impaired fasting glucose. Methods: A total of 28 elderly patients were enrolled into the vitamin D treatment group. The control group included 23 age‐, sex‐ and body mass index‐matched elderly participants. The vitamin D treatment group was treated with vitamin D 3 according to serum concentrations of 25(OH)D. Results: With supplementation, 96.0% of patients achieved a mean serum 25(OH)D concentration of 123.2 ± 59.9 nmol/L. After 4.7 ± 2.5 months of treatment, there was a significant decrease in homeostasis model assessment of insulin resistance, insulin and glucose concentrations in the vitamin D treatment group ( P = 0.007, P = 0.007, P = 0.037, respectively). Vitamin D treatment significantly increased high‐density lipoprotein cholesterol ( P = 0.037), but did not cause statistically significant differences in other lipid parameters. Conclusion: We found that vitamin D treatment might modify insulin sensitivity in the elderly with impaired fasting glucose. Geriatr Gerontol Int 2012; 12: 454–460.