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Relationship between interleukin‐6 and cerebral deep white matter and periventricular hyperintensity in elderly women
Author(s) -
Nagai Kumiko,
Kozaki Koichi,
Sonohara Kazuki,
Akishita Masahiro,
Toba Kenji
Publication year - 2011
Publication title -
geriatrics and gerontology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 57
eISSN - 1447-0594
pISSN - 1444-1586
DOI - 10.1111/j.1447-0594.2010.00686.x
Subject(s) - leukoaraiosis , medicine , hyperintensity , interleukin 6 , cerebral infarction , cardiology , logistic regression , inflammation , magnetic resonance imaging , ischemia , radiology
Aim: We evaluated the relationships between serum levels of high‐sensitivity C‐reactive protein (hsCRP) and interleukin (IL)‐6 with the severity of leukoaraiosis. Methods: One hundred and thirty‐seven elderly women who attended the Center for Comprehensive Care on Memory Disorders at Kyorin University Hospital were enrolled in this study. Leukoaraiosis was assessed by periventricular hyperintensity (PVH) score and deep white matter hyperintensity (DWMH) score. Results: Serum log IL‐6 level correlated with PVH and DWMH scores, but hsCRP did not. By multinomial logistic analysis, IL‐6 was significantly related to DWMH score, independent of age and systolic blood pressure. Conclusion: IL‐6 is presumably an important marker of leukoaraiosis, as is the case with silent cerebral infarction. Geriatr Gerontol Int 2011; 11: 328–332.