Premium
Mitochondrial haplogroups associated with lifestyle‐related diseases and longevity in the Japanese population
Author(s) -
Nishigaki Yutaka,
Fuku Noriyuki,
Tanaka Masashi
Publication year - 2010
Publication title -
geriatrics and gerontology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 57
eISSN - 1447-0594
pISSN - 1444-1586
DOI - 10.1111/j.1447-0594.2010.00599.x
Subject(s) - haplogroup , mitochondrial dna , longevity , human mitochondrial dna haplogroup , medicine , genetics , type 2 diabetes , myocardial infarction , genetic association , disease , population , haplotype , evolutionary biology , diabetes mellitus , biology , single nucleotide polymorphism , allele , gene , gerontology , environmental health , genotype , endocrinology
Recently published results on the association between metabolic syndrome, type 2 diabetes, myocardial infarction or atherothrombotic cerebral infarction and Japanese major haplogroups based on the comprehensive analysis of mitochondrial genome polymorphisms (mtSNP) in the coding region of human mitochondrial DNA (mtDNA), and longevity‐related haplogroups are described in the present review. Our aim was to provide information that would allow us to predict the genetic risk for lifestyle‐related diseases and thereby contribute to the primary prevention of these conditions. The mitochondrial genome variation is so large that a given haplogroup might consist of various subhaplogroups carrying unique and presumably functional mtSNP. The frequency of each subhaplogroup is sometimes only a few percent. Therefore, large‐scale association study is necessary for elucidating the impact of each subhaplogroup on the susceptibility to various common diseases. Geriatr Gerontol Int 2010; 10 (Suppl. 1): S221–S235.