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Dehydroepiandrosterone‐sulfate concentration in men from a Japanese longevity district
Author(s) -
Matsumoto Masami,
Ishizuka Tatsuo,
Kajita Kazuo,
Sugiyama Chiyo,
Morita Hiroyuki,
Uno Yoshihiro,
Ikeda Takahide,
Mori Ichiro,
Matsubara Kenji,
Takeda Noriyuki,
Yamakita Noriyoshi,
Yasuda Keigo
Publication year - 2007
Publication title -
geriatrics and gerontology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 57
eISSN - 1447-0594
pISSN - 1444-1586
DOI - 10.1111/j.1447-0594.2007.00424.x
Subject(s) - medicine , endocrinology , dehydroepiandrosterone sulfate , body mass index , longevity , adiponectin , dehydroepiandrosterone , insulin , androgen , hormone , insulin resistance , gerontology
Background: To clarify the effect of dehydroepiandrosterone (DHEA) on the association of DHEA with longevity in male adults in Japan, we measured DHEA‐sulfate (DHEA‐S) concentration in male adults from a Japanese longevity district. Methods: We measured serum DHEA‐S concentration, fasting plasma glucose (FPG), 2‐h plasma glucose after 75 g oral glucose loading (2hrPG), fasting insulin (FIRI) and HbA 1c , adiponectin of 34 male adults in Kokufu‐cho, one of the highest longevity districts (mean lifespan in males, 80.4 years) and those of 559 male adults in Kasamatsu‐cho (mean lifespan, 77.6 years) as control. Results: There was a significant difference of mean age between Kokufu‐cho (72 ± 7 years) and Kasamatsu‐cho (51 ± 8 years) ( P < 0.0001). FIRI levels in Kasamatsu‐cho (7.4 ± 3.3 μU/mL) were significantly higher than in Kokufu‐cho (5.3 ± 4.0 μU/mL) ( P < 0.005). The quantative insulin sensitivity check index (QUICKI) was significantly higher and homeostasis model assessment was significantly lower in Kokufu‐cho than those in Kasamatsu‐cho ( P < 0.001). Serum DHEA‐S concentrations of male adults in Kokufu‐cho, a longevity district of Japan, were significantly higher than in Kasamatsu‐cho as control, if adjusted for age, body mass index and blood glucose ( P < 0.0001). Negative correlation of DHEA‐S with age was expectedly found ( P < 0.0001) in a total of 593 male adults. Sixteen male adults in Kasamatsu‐cho and 22 male adults in Kokufu‐cho aged 68–73 years were selected. DHEA‐S concentrations of male adults in Kokufu‐cho were significantly higher than in Kasamatsu‐cho, if adjusted for body mass index, body fat composition, blood pressure, lipids values, FIRI and FPG ( P < 0.036). Conclusion: DHEA may contribute to longevity in elderly men.