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Usefulness of measuring serum markers in addition to comprehensive geriatric assessment for cognitive impairment and depressive mood in the elderly
Author(s) -
Arai Hidenori,
Takechi Hajime,
Wada Taizo,
Ishine Masayuki,
Wakatsuki Yoshio,
Horiuchi Hisanori,
Murayama Toshinori,
Yokode Masayuki,
Tanaka Makoto,
Kita Toru,
Matsubayashi Kozo,
Kume Noriaki
Publication year - 2006
Publication title -
geriatrics and gerontology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 57
eISSN - 1447-0594
pISSN - 1444-1586
DOI - 10.1111/j.1447-0594.2006.00327.x
Subject(s) - medicine , geriatric depression scale , mini–mental state examination , depression (economics) , cognition , mood , c reactive protein , physical therapy , cognitive impairment , depressive symptoms , psychiatry , economics , macroeconomics , inflammation
Background: To determine the utility of various serum markers for assessment of cognitive and mental functions in the elderly, we performed a Comprehensive Geriatric Assessment (CGA) in the out‐patient clinic in Kyoto University Hospital. Methods: We measured serum levels of dehydroepiandrosterone (DHEA), DHEA‐S, malondialdehyde low‐density lipoproteins (MDA‐LDL), and high‐sensitivity C‐reactive protein (hs‐CRP) in 145 patients to find the association of these markers with activities of daily living (ADL), cognitive impairment and depressive symptoms. Results: We found that the levels of hs‐CRP were significantly higher in patients with lower scores in Mini‐Mental State Examination (MMSE) and Kohs block design test, and higher scores in the button test, indicating that hs‐CRP may be associated with the cognitive function in elderly patients. We also found that the levels of DHEA‐S were lower in patients with higher scores (9 or over) on the Geriatric Depression Scale‐15 (GDS), indicating that DHEA‐S may be associated with depressive mode in elderly patients. Total cholesterol, high‐density cholesterol (HDL‐C), or albumin were not statistically different in each group studied. Conclusions: Thus, our data indicate that measuring hs‐CRP and DHEA‐S would be helpful to assess the cognitive function and depressive symptoms in elderly patients.