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Aging per se does not influence postprandial glucose levels in type 2 diabetes
Author(s) -
Magata Yumiko,
Oba Kenzo,
Inuzuka Yuki,
Nakano Hiroshi
Publication year - 2005
Publication title -
geriatrics and gerontology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 57
eISSN - 1447-0594
pISSN - 1444-1586
DOI - 10.1111/j.1447-0594.2005.00282.x
Subject(s) - postprandial , medicine , morning , endocrinology , area under the curve , diabetes mellitus , type 2 diabetes , plasma glucose , univariate analysis , multivariate analysis
Background: It is well known that postprandial glucose increases with aging in non‐diabetic subjects. The question we addressed is whether elderly type 2 diabetic patients with definite fasting hyperglycemia (≥ 126 mg/dL) also display increased postprandial hyperglycemia relative to their younger counterparts. Methods: Diurnal plasma glucose profiles were measured in 162 overt type 2 diabetic patients treated by diet alone (diet group) or with sulfonylureas as monotherapy (SU group). Plasma glucose concentrations were measured at 08.00 hours (before breakfast), 10.00, 12.00 (before lunch), 14.00, 18.00 (before dinner), 20.00, 24.00, 03.00, 06.00 and 08.00 hours the next morning. The postprandial glucose area under the curve (AUC) from 08.00 to 24.00 hours was calculated above the baseline level equal to the 08.00‐hours plasma glucose value, and the relationships with clinical variables, including age, were assessed. Results: There were no differences in diurnal plasma glucose profiles between the middle‐aged (< 65 years) and elderly (≥ 65 years) groups either the diet group or the SU group. Univariate analysis showed that the postprandial glucose area under the curve was related to the 08:00‐hours plasma glucose value ( R = 0.583, P < 0.001) in the diet alone group and to the duration of diabetes ( R = 0.220, P < 0.05), SU dose ( R = 0.330, P = 0.001) and urine CPR ( R = −0.229, P < 0.05) in the SU group. In multivariate analysis, postprandial glucose area under the curve was only related to 08.00 hours plasma glucose value in the diet group (R 2 of the model = 0.340, P < 0.001) and to the SU dose in SU group (R 2 of the model = 0.145, P < 0.001). Conclusion: These results suggest that aging, per se, does not influence postprandial glucose levels in overt type 2 diabetic patients.