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Electrophysiological assessment of Choto‐san treatment for stroke patients with mild cognitive impairments
Author(s) -
Yamaguchi Shuhei,
Matsubara Miwa,
Kobayashi Shotai
Publication year - 2004
Publication title -
geriatrics and gerontology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 57
eISSN - 1447-0594
pISSN - 1444-1586
DOI - 10.1111/j.1447-0594.2004.00174.x
Subject(s) - audiology , medicine , verbal fluency test , cognition , neuropsychology , oddball paradigm , stroke (engine) , event related potential , fluency , psychology , psychiatry , mechanical engineering , mathematics education , engineering
In this study, P3 event‐related brain potentials (ERPs) were measured to assess the effect of Choto‐san administration on stroke patients with mild cognitive impairments. Before and after 12‐week drug administration, P3 ERPs were recorded in a modified auditory oddball paradigm, including occasional novel sounds. Cognitive functions were also assessed with the Mini Mental State Examination (MMSE) and verbal fluency test. The drug administration improved significantly the MMSE and verbal fluency test scores. P3 latency to target sounds was shortened in association with reduced reaction time to the sounds, after the drug administration. Furthermore, P3 amplitude to novel sounds was enlarged and its topography shifted from central to frontal sites. These results indicate that Choto‐san improves electrophysiological indices related to higher cognitive function in addition to neuropsychological test scores in stroke patients with mild cognitive impairments.