Open AccessEpigenetics in assisted reproductive technology
Author(s) -
KATAGIRI YUKIKO,
SHIBUI YUKIHIRO,
NAGAO KOICHI,
MIURA KAZUKIYO,
MORITA MINETO
Publication year - 2007
Publication title -
reproductive medicine and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.005
H-Index - 22
eISSN - 1447-0578
pISSN - 1445-5781
DOI - 10.1111/j.1447-0578.2007.00168.x
Subject(s) - angelman syndrome , epigenetics , offspring , assisted reproductive technology , reproductive medicine , reproductive technology , medicine , genetics , biology , pregnancy , infertility , lactation , gene
It has been reported that the rates of epigenetic disorders such as Angelman syndrome (AS) and Beckwith–Wiedemann syndrome (BWS) are high in offspring conceived by assisted reproductive technology (ART). Angelman Syndrome is characterized by intellectual disability and BWS is known as large offspring syndrome (LOS). Weight abnormalities have also been reported in cloned animals. Possible factors underlying these findings include inherent gamete characteristics, influence of in vitro culture and peculiarity of ART methods. It is important to conclusively determine whether such epigenetic abnormalities are present in children conceived by ART, so as to consider the health of next generations.