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Intravenous immunoglobulins as treatment of severe cutaneous polyarteritis nodosa
Author(s) -
Marie I.,
Miranda S.,
Girszyn N.,
Soubrane J.C.,
Vandhuick T.,
Levesque H.
Publication year - 2012
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/j.1445-5994.2012.02739.x
Subject(s) - medicine , polyarteritis nodosa , refractory (planetary science) , antibody , intravenous immunoglobulins , intravenous immunoglobulin therapy , dermatology , surgery , vasculitis , immunology , disease , physics , astrobiology
We describe three patients with severe refractory cutaneous polyarteritis nodosa, resulting in painful ulcers involving the lower limbs and causing toe necrosis. Due to the severity of the cutaneous manifestations, the three patients received intravenous immunoglobulins at a dose of 1 g/kg/day for 2 days monthly. After the second intravenous immunoglobulin infusion, skin signs dramatically improved and completely healed after the third intravenous immunoglobulin infusion. Our findings indicate that intravenous immunoglobulins can be included in a therapeutic strategy to treat refractory cutaneous polyarteritis nodosa.