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Quality of life: a potentially useful measure to indicate subclinical flares in Crohn disease
Author(s) -
Cámara R. J. A.,
Juillerat P.,
Pittet V.,
Schoepfer A. M.,
Begré S.,
von Känel R.
Publication year - 2012
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/j.1445-5994.2011.02472.x
Subject(s) - medicine , subclinical infection , quality of life (healthcare) , exacerbation , cohort , odds ratio , odds , disease , inflammatory bowel disease , logistic regression , crohn's disease , ulcerative colitis , nursing
Abstract Background: While quality of life (QoL) is a well‐recognised outcome measure of Crohn disease (CD) activity, its influence on other outcome measures, including exacerbation of CD is poorly understood. If QoL measures were to be associated with intestinal inflammatory activity, they might be useful for early detection of subclinical flares. Aims: We hypothesised that low QoL might be associated with subsequent CD flares. Methods: A cohort of 318 adult CD patients was observed for 1 year after assessment of baseline characteristics. Data were collected in Swiss university hospitals, regional hospitals and private practices. At inclusion, patients completed the Inflammatory Bowel Disease QoL Questionnaire ( gastrointestinal QoL; range: 32 to 224 points) and the Short Form‐36 Health Survey ( general QoL; range: 35 to 145 points). During follow up, flares were recorded. Binary logistic regression was performed to estimate the relation between QoL and the odds of subsequent flares. Results: A twofold decrease in the odds of flares (99% CI: 1.1; 4.0) per standard deviation of gastrointestinal QoL and a threefold decrease (99% CI: 1.5; 6.2) per standard deviation of general QoL were observed. Conclusions: The close association between QoL and subsequent flares suggests that QoL measures might be useful in detecting upcoming flares before they become clinically apparent.