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Multiple myeloma presenting with a fever of unknown origin and development of thrombotic thrombocytopenic purpura post‐bortezomib
Author(s) -
Moore H.,
Romeril K.
Publication year - 2011
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/j.1445-5994.2011.02458.x
Subject(s) - bortezomib , medicine , multiple myeloma , thrombotic thrombocytopenic purpura , purpura (gastropod) , immunology , platelet , ecology , biology
Multiple myeloma rarely presents with a fever of unknown origin and diagnosis may be delayed. We describe a case of myeloma presenting in this way with raised serum‐free light chains and TP53 deletion on cytogenetics. The patient developed thrombotic thrombocytopenia purpura (TTP) following bortezomib therapy but recovered spontaneously and was successfully re‐challenged. We believe this is only the second case to describe this phenomenon post‐bortezomib and the first to rechallenge the patient successfully without further recurrence of TTP. Possible mechanisms for this successful rechallenge are discussed.