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Transfusion‐related acute lung injury in a neutropenic patient
Author(s) -
Finlayson J.,
Grey D.,
Kavanagh L.,
Witt C.
Publication year - 2011
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/j.1445-5994.2010.02366.x
Subject(s) - medicine , transfusion related acute lung injury , intensive care medicine , diffuse alveolar damage , emergency medicine , lung , pulmonary edema , acute respiratory distress
Transfusion‐related acute lung injury (TRALI) is a leading cause of transfusion related morbidity and mortality. Current concepts regarding the pathogenesis of this disorder imply a “two‐hit” model in which neutrophils are sequestered in the pulmonary capillary bed, and subsequently activated by substances in the transfused blood product. We report a case of TRALI in a patient with neutropenia and discuss the possible factors contributing to the respiratory symptoms in this patient. We also emphasise the importance of recognising mild cases of TRALI in order to investigate the implicated donor/s appropriately, and to minimise the risk for more severe episodes in other patients.