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Transmission of triple‐class, drug‐resistant HIV‐1 in Australia
Author(s) -
Tong W. W. Y.,
McAllister J.,
White P. A.,
Kelleher A. D.,
Carr A.
Publication year - 2010
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/j.1445-5994.2010.02296.x
Subject(s) - medicine , transmission (telecommunications) , human immunodeficiency virus (hiv) , drug , drug class , class (philosophy) , virology , pharmacology , artificial intelligence , telecommunications , computer science
We report the first two cases of transmitted triple‐class, drug‐resistant HIV‐1 in Australia. Baseline testing of a newly diagnosed man showed four reverse transcriptase resistance mutations (affecting two drug classes) and six protease resistance mutations. A source patient was identified, and a likely second case newly infected 1 year later, suggesting sequential transmission. This raises therapeutic implications for the individual patients, as well as public health concerns.