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Cardiotoxicity with 5‐fluorouracil and capecitabine: more than just vasospastic angina
Author(s) -
Stewart T.,
Pavlakis N.,
Ward M.
Publication year - 2010
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/j.1445-5994.2009.02144.x
Subject(s) - medicine , cardiotoxicity , capecitabine , fluorouracil , vasospastic angina , angina , coronary vasospasm , cardiology , chemotherapy , cancer , colorectal cancer , myocardial infarction
In this case series we present a variety of different cardiac toxicities with 5‐fluorouracil and its pro‐drug capecitabine, including myocardial infarction, cardiomyopathy, sinoatrial and atrioventricular node dysfunction, tako‐tsubo cardiomyopathy and QT prolongation with torsade‐de pointes ventricular tachycardia. We stress the fact that while vasospasm is a well‐recognized side‐effect of this class of chemotherapeutic agent, broader cardiotoxicity is commonly seen and an increased awareness of the range of toxicity is necessary if repeat toxicity is to be avoided.