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Reversible posterior encephalopathy syndrome associated with bortezomib
Author(s) -
Terwiel E.,
Hanrahan R.,
Lueck C.,
D'Rozario J.
Publication year - 2010
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/j.1445-5994.2009.02097.x
Subject(s) - medicine , bortezomib , encephalopathy , posterior reversible encephalopathy syndrome , pathophysiology , vasomotor , magnetic resonance imaging , multiple myeloma , radiology
Reversible posterior encephalopathy (RPES) is an uncommon neurological syndrome that is being increasingly reported in association with anti‐neoplastic therapies. The first case of reversible posterior encephalopathy associated with the proteosome inhibitor bortezomib is described and the reported experience of the occurrence of RPES with other antineoplastic therapies reviewed. Dysregulation of cerebral vasomotor autoregulation is postulated as the underlying pathophysiology in this case of bortezomib associated RPES.