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Intravascular haemolysis in a patient on ceftriaxone with demonstration of anticeftriaxone antibodies
Author(s) -
Dinesh D.,
Dugan N.,
Carter J.
Publication year - 2008
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/j.1445-5994.2008.01656.x
Subject(s) - medicine , ceftriaxone , haemolysis , serology , antibody , complication , drug , coombs test , immunology , gastroenterology , antibiotics , pharmacology , microbiology and biotechnology , biology
Drug‐induced haemolytic anaemia can be life threatening. We report a case of ceftriaxone‐induced severe haemolytic anaemia in a previously healthy 68‐year‐old woman. The patient had a positive direct antiglobulin test (anti‐C3d positive, anti‐immunoglobulin G negative). Serological tests showed ceftriaxone‐specific antibodies. The patient recovered after cessation of the drug. This complication may cause milder anaemia and thus be poorly recognized.