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Prevalence of glucose‐6‐phosphate dehydrogenase deficiency in Northern Greece
Author(s) -
Ntaios G.,
Chatzinikolaou A.,
Tomos C.,
Manolopoulos C.,
Karalazou P.,
Nikolaidou A.,
AlexiouDaniel S.
Publication year - 2008
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/j.1445-5994.2007.01618.x
Subject(s) - medicine , glucose 6 phosphate dehydrogenase deficiency , glucosephosphate dehydrogenase deficiency , glucose 6 phosphate dehydrogenase , population , demography , enzyme deficiency , pediatrics , dehydrogenase , environmental health , enzyme , biology , biochemistry , sociology
Abstract Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency affects more than 400 million persons worldwide. Its distribution varies significantly among different geographic regions and different population groups. Purpose of our study was to estimate its prevalence in Northern Greece. The dataset comprised 5161 newborns and adults who were screened for G6PD deficiency between July 2001 and March 2007. G6PD deficiency was detected by the dye reduction method. In the screened group, 6.3% of subjects were G6PD deficient. Moderate enzyme deficiency was shown in 139 individuals (2.7%). Complete deficiency was identified in 3.7%. The prevalence of G6PD deficiency in Northern Greece is much higher compared with the general Greek population. Moreover, G6PD prevalence in the male sex is much higher – almost double – that in the female sex.