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High‐rate pulmonary involvement in autoimmune pancreatitis
Author(s) -
Hirano K.,
Kawabe T.,
Komatsu Y.,
Matsubara S.,
Togawa O.,
Arizumi T.,
Yamamoto N.,
Nakai Y.,
Sasahira N.,
Tsujino T.,
Toda N.,
Isayama H.,
Tada M.,
Omata M.
Publication year - 2006
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/j.1445-5994.2006.01009.x
Subject(s) - medicine , autoimmune pancreatitis , prednisolone , gastroenterology , pancreatitis , complication , retroperitoneal fibrosis , pulmonary fibrosis , respiratory disease , respiratory failure , lung , fibrosis
Autoimmune pancreatitis (AIP) has extrapancreatic complications such as Sjögren's syndrome, retroperitoneal fibrosis and sclerosing cholangitis. We studied 30 patients with AIP. Of these, we identified pulmonary involvement in four patients during follow up. Among them, two patients had respiratory failure. They showed good response to steroid therapy, but a higher dose of prednisolone was necessary to maintain remission than that required in biliary involvement. Elevation of immunoglobulin G 4 and Krebs von den Lungen‐6 levels were characteristic of pulmonary involvement. They may be useful for early detection of pulmonary complication.