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Direct comparison of 18 F‐fluorodeoxyglucose coincidence gamma camera tomography with gallium scanning for the staging of lymphoma
Author(s) -
Lin P.,
Chu J.,
Kneebone A.,
Moylan E.,
Jalaludin B.,
Pocock N.,
Kiat H.,
Rosenfeld D.
Publication year - 2005
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1111/j.1445-5994.2004.00744.x
Subject(s) - medicine , nuclear medicine , coincidence , gamma camera , gallium , tomography , fluorodeoxyglucose , lymphoma , radiology , positron emission tomography , medical physics , pathology , chemistry , alternative medicine , organic chemistry
Background : The present study compared the performance of 18 F‐fluorodeoxyglucose (FDG) positron emission tomography (PET) using a coincidence dual‐head gamma camera (FDG Co‐PET) with 67 gallium scinti graphy (GS) in pretreatment staging of lymphoma. Methods : A total of 46 patients underwent FDG Co‐PET, computed tomography (CT) scanning and GS for pretreatment staging of lymphoma (40 newly diagnosed and recurrence) between November 1997 and December 1999. Results : Histological subgroups comprised low grade (8 patients), intermediate grade (25) high‐grade (3) non‐Hodgkin's lymphoma and Hodgkin's disease (10). Based on clinical assessment, CT scan findings and biopsy, 100 nodal sites and 15 extra‐nodal sites were deemed positive. FDG Co‐PET was superior to GS in nodal site positivity rate (97% vs 79%, P < 0.0001). Compared with GS, FDG Co‐PET detected 39 more abnormal sites in 22 patients (48%), of which 28 sites were validated by biopsy, CT and/or progress FDG Co‐PET scanning. There was only one proven false negative FDG site in the spleen. CT + FDG Co‐PET led to upstaging in 2 patients (4%), compared to CT + GS. Conclusion : FDG Co‐PET shows potential for providing an accurate means for pretreatment staging of lymphoma and can detect extra sites of disease activity compared to GS. (Intern Med J 2005; 35: 91–96)