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Type 2 diabetes towards the new millennium – the relative importance of glycaemic versus lipid control
Author(s) -
Florkowski C. M.,
Scott R. S.
Publication year - 1999
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1999.tb00692.x
Subject(s) - medicine , diabetes mellitus , type 2 diabetes , original research , citation , family medicine , library science , endocrinology , computer science
The prevalence of type 2 diabetes is set to increase. The UKPDS has shown that better average glycaemic control over time leads to a reduction in microvascular complications. Macrovascular outcomes are also reduced in overweight subjects treated with metformin. The UKPDS and our own data, however, show that the natural history of type 2 diabetes is one of progressive deterioration in glycaemic control despite treatment. Lipid parameters emerges as the strongest predictors of outcomes in type 2 diabetes and suggest where therapeutic endeavours might best be directed. Ongoing trials of lipid-modifying therapies in type 2 diabetes will help to substantiate this. In the meantime, efforts to improve glycaemic control should not be pursued to the exclusion of other abnormalities that may have a greater relevance to outcomes of type 2 diabetes. There is an urgent need for better prevention and intervention strategies as we approach the new millennium.