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GUSTO II Trail
Author(s) -
Aylward Philip
Publication year - 1993
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1993.tb04760.x
Subject(s) - medicine , thrombolysis , antithrombin , hirudin , myocardial infarction , unstable angina , heparin , cardiology , angina , intensive care medicine , thrombin , platelet
The GUSTO II trial will investigate the role of antithrombin therapy in acute coronary syndromes, comparing standard doses of heparin with the specific antithrombin agent recombinant hirudin. The two drugs will be compared as primary therapy in patients with unstable angina or patients with myocardial infarction (MI) unsuitable for thrombolysis, and as post thrombolysis treatment in patients who fulfil standard criteria for thrombolysis therapy. A total of 12,000patients will be studied in a global, multifactorial trial.