THE AUSTRALIAN RHEUMATOLOGY ASSOCIATION

The followina are abstracts of papers presented at the 35th Annual Scientific Meeting of the Australian Rheumatology Association, held in Perth, Western Australia, 1–4 December. 1991 PREVENTlON OF CORTICOSTEROID OSTEOPOROSIS, P.N. Sambrook*, J. Birmingham, P. Kelly, T. Nguyen, N. Pocock, J. A. Eisman RHEUMATOID ARTHRITIS IN TWINS BASED ON THE AUSTRALIAN TWIN REGISTRY (ATR), N. Bellamy*, D. Duffy 2 , N. Martin 2 and J. Matrhews 3 . 1 Epidemiology and Biostatirtics HEPARIN, PENTOSAN POLYSULPHATE AND DEXTRAN SULPHATE TRIGGER TYPE I COLLAGEN‐INDUCED VASCULAR TUBE FORMATION IN VITRO. Chris Jackson, Irina Giles, Andrew Nethery and Les Schrieber THE T‐CELL ANTIGEN RECEPTOR CLONOTYPIC CHAINS INTERACT VIA DISTINCT REGIONS WITH THE CD3 CHAINS. N. Manolios*, F. Letourner, J. Bonifacino and R. Klausner MIMICRY VERSUS SELF IMMUNIZATION: DEFINITION OF A DlSCONTINUOUS EPITOPE AT THE N‐TERMINUS OF THE La(SS‐B) RIBONUCLEOPROTETN ANTIGEN. L. J. McNeilage, K. Umapathysivam and T. Gordon METABOLISM OF ARTICULAR CARTILAGE IN AN EXPERIMENTAL MODEL OF EARLY OSTEO‐ARTHRITIS. P. Ghosh*, Y. Numata, S. Smith, R. Read + and S. Armstrong + FIBROMYALGIA SYNDROME ‐ A RHEUMATAUTOLOGY. Milton L. Cohen THE CHONDROPROTECTIVE DRUGS, PENTOSAN POLYSULFATE AND ARTEPARON, STIMULATE COLLAGENASE AND INHIBIT STROMELYSIN ACTIVITIES IN VITRO . Andrew Nethery* 1 , Irina Giles 1 , Leslie Schrieber 1 , Peter Brooks 1 Dan Burkhardt 2 , Peter Ghosh 2 , Robert L. O'Grady 3 , and Howard G. Welgus 4 THE EFFECTS OF ORAL ADMINISTRATION OF CALCIUM PENTOSAN POLYSULPHATE (CaPPS) ON CARTILAGE AND SYNOVIAL FLUID COMPONENTS IN A RABBIT MODEL OF INFLAMMATORY ARTHRITIS. M. Smith* and P. Ghosh INCREASED SYNOVIAL FLUID KERATAN SULPHATE CONCENTRATION AND FLUX OCCUR FOLLOWING TREATMENT OF OSTEOARTHRITIS OF THE KNEE WITH INDOMETHACIN AND AZAPROPAZONE. B Will*, C. Caspersz, J. Barnes, N. Hall THE USE OF KERATAN SULPHATE (KS) EPITOPES IN SYNOVIAL FLUID AS AN INDEX OF CARTILAGE INTEGRITY IN EARLY OA AND AS A MARKER OF RESPONSE TO DRUG THERAPY. P. Ghosh*, C. Holbert, C. Wells, S. Armstrong*, P. Wilson + and R. Read + EFFECTS OF NEUROPEPTIDES ON ARTICULAR CARTILAGE CHONDROCYTE FUNCTION. Dale A. Halliday, Julian D. McNell, *W. H. Betts & + Raffaele Scicchitano IDIOPATHIC CHONDROLYSlS OF THE HIP Case Report and Studies on Chrondrocyte Proteoalycan Metabolism G.A.C. MAJOR*, J. MELROSE**, A. JACOBY**, P. GHOSH** ACTIVATION OF THE MACROPHAGE RESPIRATORY BURST CORRELATES WITH PROTEIN TYROSINE KINASE‐MEDIATED PHOSPHORYLATION Simon P. Green, Wayne A. Phillips, and John A. Hamilton THE KINETICS OF SYNOVIAL HYALURONAN (HYALURONIC ACID; HA) IN NORMAL AND ACUTELY INFLAMED JOINTS. JRE Fraser*, TJ Brown*, WG Kimpton*, UBG Laurent† and BK Pierscionek* ACTIVATION OF NEUTROPHILS BY TACHYKININS: EFFECTS ON OXIDATIVE METABOLISM AND ANTIBODY‐DEPENDENT CELL‐MEDlATED CYTOTOXICITY. A Wozniak*, R Scicchitano§ and WH Betts DETERMINANTS OF SYNOVIAL FLUID LACTATE CONCENTRATION. M. J. James* and L. G. Cleland COLLAGEN ANTIBODIES IN EARLY ARTHRITIS M. J. Rowley 1 *, A. Stockman 2 , C. A. Brand 2 , K. D. Muirden 2 , I. R. Mackay 1 REGULATION OF ANTI‐FIBRINOLYTIC ACTIVITY IN MONOCYTIC CELLS. J. L. Dickinson and T. M. Antalis* IgG SUBCLASSES OF COLLAGEN ANTIBODIES M. J. Rowley* Analysis of TNFα and IL‐1β and their inhibitors in Rheumatoid and Osteoarthritic synovial tissue by Immunohistochemistry and by Bioassay and ELISA of Explant cultures. V. Milwav, K. Rogers and K. D. Muirden FIBROBLAST GROWTH FACTORS IN CONNECTIVE TISSUE DISEASE ASSOCIATED INTERSTITIAL LUNG DISEASE: ASSOCIATION WITH DISEASE ACTlVlTY AND IDENTlFlCATlON AS TNF‐α, PDGF AND FIBRONECTIN. S. C. Thornton*, R. Penny and S. N. Breit DETECTION OF COLONY‐STIMULATING ACTIVITY IN SYNOVIAL FLUID IN MULTICENTRIC RETICULOHISTIOCYTOSlS. Michael J. Elliott*; David A Kmdiah and David Barraclough EFFECT OF GONADAL STEROIDS ON THE PRODUCTlON OF INTERLEU‐KIN‐1 AND INTERLEUKIN‐6 BY PERIPHERAL BLOOD MONONUCLEAR CELLS IN VITRO. ZG Li*, VA Danis and PM Brooks FAMILY STUDIES IN AUTOIMMUNOLOGY A STUDY USING A RECOMBINANT SS.B/La R. Owe‐Young and A. Sturgess REACTIVITY OF HUMAN AUTOANTIBODIES TO THE RNA BINDING DOMAIN OF THE La(SS‐B) RIBONUCLEOPROTEIN AUTOANTIGEN. M. Rischmueller, L. J. McNeilage, K. Umapathysivam and T. Gordon USE OF A MOLECULARLY CLONED HUMAN S.S.B ANTIGEN TO DETECT ANTI‐SS.B ANTIBODIES R. Owe‐Young, S. Horn, J. Edmonds, A. Sturgess PCR DETECTS CLONALITY IN PERIPHERAL BLOOD OF PATIENTS WITH MIXED CRYOGLOBULINAEMIA R. Kwiatek* l , A. Bennett, K. Trainor, M. Brisco, A. Morley and P. Roberts‐Thomson A COMMON IDIOTYPE AND IMMUNOGLOBULIN GENE USAGE IN ANTI‐PHOSPHOLIPID ANTIBODIES. A. W. Hohmann, V. Boswanra, R. Comacchio, A. Neville and J. Bradley YTTRIUM SYNOVECTOMY: A META‐ANALYSIS OF THE LITERATURE G. JONES* SYNOVIAL FLUID CELLS, SYYOVIAL FLUID AND INTERLEUKIN‐4 ACTIVITY. P. H. Hart & M. J. Ahern LENGTH OF STAY IN ACTIVE RHEUMATOID ARTHRITIS ‐ A PROSPECTIVE STUDY. G. Jones*, B. J. Smith, D. Mathers, G. A. C. Major, S. Ratnarajah, J. S. Glass DISCITIS: FIVE CASE PRESENTATIONS WITH DISCUSSION OF CLINICAL FEATURES AND INVESTIGATIVE FINDINGS. DA Kandiah*, DRE Barraclough, KD Muirden, HM Moran and G Buirski THE ROLE OF BONE SCINTIGRAPHY IN CHRONIC LOW BACK PAIN: COMPARISON OF SPECT AND PLANAR IMAGES AND ZYCAPOPHYSIAL JOINT INJECTION. A. C. Schwarzer*, A. M. Scott, S. Wang, R. Hoschl, J. C. Wiseman, R. A. Conner, D. Coote and R. Laurent THE ROLE OF THE ZYGAPOPHYSIAL JOINT IN CHRONIC LOW BACK PAIN. A.C.Schwarzer*, S. Wann, R. Laurent, P. McNauaht and P. M. Brooks A MULTIDISCIPLINARY APPROACH TO THE MANAGEMENT OF CHRONIC PAIN EXPERIENCE AT THE NORTH SHORE PAIN CENTRE. A.C.Schwarzer*, C. Needs, R. Gardner, L. Tonkin, L. Baczocha and E. Mornan TOTAL HIP ARTHROPLASTY IN THE YOUND ARTHRITIC PATIENT J.F. Bleasejl*, H. D. D. Tyer, J. R. York, J. Korber FACTOR VIII INHIBITORS IN RHEUMATOID ARTHRITIS J. F. Bleasel*, J. R. York, K. A. Rickard JOINT REPLACEMENT IN PATIENTS WITH PAGETS DISEASE OF BONE S. Preston*, J. Hassall, J Korber, H. York, H. Tyer DEPRESSED BONE MINERAL DENSITY IN ANKYLOSING SPONDYLITIS IS NOT ASSOCIATED WITH ALTERED MARKERS OF BONE TURNOVER. R. Will*, R. Palmer, R. Woodward, F. Ring, A. Calin and A. K. Bhalla THE PROBLEM OF OSTEOPOROSIS (OP) IN RHEUMATOID ARTHRITIS (RA). M.Marahani*, K.Chaudhuri, J.Heussler, T.Diamond, P. Butler and J. Edmonds A “FLEXICURVE” IS A PRECISE INSTRUMENT FOR OBTAINING REPRODUCIBLE MEASUREMENTS OF DORSAL, SPINAL CURVATURE IN ANKYLOSING SPONDYLITIS. R. Will*, P. Gaisford, B. Davey, J. Hall, R. Harrison, V. Papadoikos, H. Sewell, A. K. Bhalla and A. Calin POSTMENOPAUSAL BONE LOSS IN RHEUMATOlD ARTHRITIS: EFFECT OF ESTROGENS AND ANDROGENS P. Samhrook*, J. Birmineharn, G. D. Champion, P. Kelly, S. Kempler, J. A. Eisman RENAL FUNCTIONAL ABNORMALITIES IN ASSOCIATION WITH RHEUMATOID ARTHRITIS (RA). P. Savvas*, L.S. Ibels, A. Z. Gvory and P.M. Brooks SYDNEY SCLERODERMA EPIDEMIOLOGY STUDY 1974–1988. DECEASED DATA ‐ PRELIMINARY ANALYSIS. H Englert, *P Brooks, R Penny METASTATIC CARCINOMATOUS ARTHRITIS. RADIOLOGICAL AND CYTOLOGICAL FINDINGS. A. Stockman*, S. K. Tang#, A. Khan+ and G. Buirski** INTERLEUKIN‐1β AND SOLUBLE INTERLEUKIN‐2 RECEPTOR LEVELS AS DISEASE ACTIVITY INDICATORS IN SCLERODERMA Mark Patrick, Bruce Kirkham, Meredith Graham, Leonard C. Harrison SEVERE PRIMARY ERYTHROMELALGIA. A WARE CAUSE OF PAINFUL HANDS AND FEET IN CHILDHOOD. S. M. Randle*, H. Gold, P. Lawson and N. Roberts DETERMINANTS OF JOINT HYPERMOBILITY IN A YOUND ADULT POPULATION. L. M. March*, P. Brennan, A. J. Silman LOWER POWER LASER THERAPY IN RA Heussler J K, Sturgess A D IS THERE A LINK BETWEEN B CELL DYSCRASIAS AND AUTOIMMUNITY? Hardiman K. L., Sturgess, A. D ABNORMAL THERMOGRAPHIC PATTERNS OCCUR OVER THE SHOULDER AND UPPER LIMB IN ANKYLOSING SPONDYLITIS. R. Will, M. Burke, A. Tooke, D. Elvins, A. Calin and F. Ring OUTCOME FOLLOWING LUMBOSACRAL ROOT DECOMPRESSION: A THERMOGRAPHIC ASSESSMENT. R. Will*, D. Elvins, S. Bulstrode, P. Bliss, G. Evison and F. Rina IS MCTD A DISTINCT RHEUMATIC DISEASE? Chen Shun‐le, Shen Nan, Yang Fu‐Tiang, Fan Li‐an SELECTIVE BRACHIAL PLEXUS INFUSION IN DIAGNOSIS AND TREATMENT OF REFRACTORY NECK AND ARM PAIN ‐ A PRELIMINARY REPORT A.‐L. Leslie, G.D. Champion, *M. McKell & M.L. Cohen CORRELATION BETWEEN A SELF‐REPORTED QIJESlIONNAIRE AND OTHER MEASURES OF DISEASE ACTlVITY IN RHEUMATOID ARTHRITIS. K. Chaudhuri*, M. Marabani, J. Heussler, J. Edmonds SUBTYPES OF ANCA AND THEIR CLINICAL ASSOCIATIONS. M. N. Lassere*, S. Horn, A. D. Sturgess AN ANIMAL MODEL OF METHOTREXATE HEPATOTOXICITY. M. J. Ahern, M. A. Jenner, D. Uzelin, P de la, M. Hall DRAINAGE PROCEDURES IN SEPTIC ARTHRITIS ‐ A RETROSPECTIVE REVIEW. R. A. Kwiatek*, M. D. Smith, M. J. Ahern, P. J. Roberts‐Thomson DOES STEROID PULSING INFLUENCE THE EFFICACY AND TOXICITY OF CHRYSOTHERAPY? A DOUBLE BLIND, PLACEBO CONTROLLED STUDY. M. D. Smith, M. J. Ahern and P. J. Roberts‐Thomson PSYCHOLOGICAL EFFECTS OF PULSE METHYLPREDNISOLONE IN RHEUMATOID ARTHRITIS M. Bleakley, M. D. Smith, R. Kwiatek, P.J. Roberts‐Thomson, D. Cosh, M.J. Ahern THE PHARMACOKINETICS AND PHARMACODYNAMICS OF NAPPOXEN IN SYNOVIAL FLUID AND PLASMA. R. O. Day*, K. M. Williams, G. Geisslinger, and #H. Francis and #J. Vial CASTANOSPERMINE AND ADJUVANT ARTHRITIS D. Mathers, K. Bowen, G. Major, D. Willenburg, C. Parish and W. Cowden EFFECT OF THALIDOMIDE ON POLYMORPHONUCLEAR LEUKOCYTE FUNCTION.* K. M. Williams, W Ye, F. Lohrer, J. Guille, R. O. Day, and #G. Blaschke A REVIEW OF ALLOPURINOL DESENSITIZATION IN PATIENTS WITH GOVT, CHRONIC RENAL INSUFFICIENCY AND PREVIOUS ALLOPURINOL TOXICITY. T.M. Dawson*, P.F.J. Ryan and S. Hall ANALGESIC EFFICACY OF IBUPROFEN IN HUMAN EXPERIMENTAL PAIN. J. Walker, A Chandler, R. Sheather, and R Day MISOPROSTOL AUGMENTS THE ANTI‐INFLAMMATORY ACTIVITY OF NON‐STEROID, CORTICOSTEROID AND ANTOXIDANT DRUGS IN RATS. M.W. Whitehouse*, D. Haynes and B. Vernon‐Roberts HOW MANY PATIENTS SHOULD WE STUDY IN ANTI‐RHEUMATIC DRUG TRIALS? N. Bellamy*, G.A. Wells 2 and J. Campbell 1 THE EFFECT OF SLOW ACTING ANTI‐RHEUMATIC DRUGS (SAARDS) AND COMBINATIONS OF SAARDS ON THE PRDUCTION OF CYTOKINES BY MONOCYTES. VA Danis*, Gradislava M. Franic and PM Brooks ACYCLOVIR (ACV) IN RHEUMATOID ARTHRITIS (RA): A PILOT STUDY. W Harrison, A Cargeeg, P Hanrahan CIRCULATING CYTOKINE LEVELS IN PATIENTS WITH RHEUMATOID ARTHRITIS: RESULTS OF A DOUBLE BLIND TRIAL WITH SULPHASALAZINE. VA Danis*, Gradislava M Franic, RM Lament and PM Brooks AN ASSESSMENT OF CARTILAGE DEGRADATION AND SYNTHESIS IN THE KNEE JOINT FOLLOWING INTRAARTICULAR TRIAMCINOLONE HEXACETONIDE. R. Will*, J Armas, J. Barnes AUROTHIOMALATE AND OTHER METAL IONS INHIBIT THE BINDING OF AP1 TRANSCRIPTION FACTOR TO ITS DNA RESPONSE ELEMENT. M.L. Handel*, C. K. W. Watts, R. O. Day and R. L. Sutherland TREATMENT WITH METHOTREXATE (MTX) REDUCES INTERLEUKIN‐1β (IL‐1β), KERATAN SULPHATE (KS) AND LEUKOCYTE CONCENTRATIONS IN RHEUMATOID SYNOVIAL FLUID (SF). G. J. Carroll R. Thomas, M. C. Bell, B. A. Laing CLEAVAGE OF CARTILAGE PROTEOGLYCANS BY STROMELYSINS AJ Fosano*, PJ Neame, TE Hardinaham, G Murphy MACROPHAGE FUNCTION IN GM‐CSF‐TRANSGENIC MICE. Michael J. Ellion*, Beverley Faulkner‐Jones and Donald Metcalf MIXED CONNECTIVE TISSUE DISEASE (MCTD): AN ELEVEN YEAR FOLLOW‐UP. M.N.Lassere*, L. Portek, A. D. Sturgess