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Recently characterised autoantibodies and their clinical significance
Author(s) -
Sturgess A.
Publication year - 1992
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1992.tb02126.x
Subject(s) - autoantibody , anti nuclear antibody , medicine , crest syndrome , polymyositis , rna polymerase iii , scleroderma (fungus) , immunology , myositis , rna splicing , antibody , rna , connective tissue disease , autoimmune disease , genetics , gene , biology , pathology , rna polymerase , inoculation
Multisystem autoimmune diseases such as systemic lupus uythcmatosus (SLE), primary Sjögrcn's syndrome (SS), sclcroderma and polymositis are characterised by the presence of antinuclear antibodies (ANAs). Immunoblotting and cDNA cloning studies reveal that the autoantigens of the multisystem autoimmune dixsucs are important proteins involved in nucleic acid metabolism, including tRNA charging, intron splicing, DNA uncoiling, and RNA polymuase co‐factors. Each spaific syndrome associates with a restricted variety of ANAs e.g. anti‐La with primary SS, anti‐Sm with SLE, and‐synthetase enzymes with myositis, and‐topoisomerase 1 (Scl 70) with scleroderma, and anti‐centromere with CREST. Precise characterisation of an ANA provides valuable diagnostic and prognostic information, and should be performed when an ANA is detected.