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POEMS syndrome, osteosclerotic myeloma and Castleman's disease: a case report
Author(s) -
Bosco J.,
Pathmanathan R.
Publication year - 1991
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1991.tb01353.x
Subject(s) - organomegaly , poems syndrome , medicine , polyneuropathy , multiple myeloma , monoclonal gammopathy , pathology , monoclonal gammopathy of undetermined significance , disease , dermatology , castleman disease , monoclonal , immunology , antibody , monoclonal antibody
Peripheral neuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes are often the presenting features of the POEMS syndrome. Approximately 50% of these are associated with osteosclerotic myeloma, a rare variant of multiple myeloma and some with Castlemanapos;s disease, an unusual lympho‐proliferative disorder. The underlying pathogenetic mechanisms have not been elucidated but amelioration of symptoms with the disappearance of the M‐component suggests possible etiopathogenic mechanisms. We present a 40‐year‐old woman with manifestations of all three disorders. (Aust NZ J Med 1991; 21:454–456.).