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Medroxyprogesterone induced Cushing's syndrome
Author(s) -
Learoyd Diana,
McElduff Aidan
Publication year - 1990
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1990.tb00433.x
Subject(s) - medicine , cushingoid , medroxyprogesterone acetate , cushing syndrome , medroxyprogesterone , endocrinology , glucocorticoid , dexamethasone , hormone
A 74‐year old female taking medroxyprogesterone acetate (MPA) presented with Cushing's syndrome together with low serum cortisol and plasma ACTH and an impaired response to synthetic ACTH (Synacthen, CIBA). When the medroxyprogesterone therapy was ceased the cushingoid features resolved and serum cortisol, ACTH and ACTH responsiveness all returned to normal. The MPA was acting as an exogenous glucocorticoid causing Cushing's syndrome.