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PRIMARY CEREBRAL LYMPHOMA: PRESENTATION OF EIGHT CASES AND REVIEW OF THE LITERATURE
Author(s) -
BOADLE D. J.,
TATTERSALL M. H. N.
Publication year - 1989
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1989.tb00334.x
Subject(s) - medicine , presentation (obstetrics) , radiological weapon , chemotherapy , incidence (geometry) , lymphoma , surgery , pediatrics , radiology , pathology , physics , optics
Eight cases of primary cerebral lymphoma (PCL) are presented, being the largest Australian series of this rare condition reported to date. The clinical, radiological, anatomical and histological features were found to be comparable with those of patients reported in other series between 1954 to 1986. The precise treatment of PCL remains undetermined due to its rarity and apparent heterogeneity. Whole brain irradiation forms the basis of therapy although the role of prophylactic spinal irradiation, surgery and chemotherapy have not been defined. Response to corticosteroids and chemotherapy has been documented. Reported cases associated with the acquired immune deficiency syndrome (AIDS) are discussed. With an anticipated increase in the numbers of cases of AIDS, the incidence of related PCL will also increase. Large, multicentric trials are required to further delineate optimal treatment.