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ACUTE NECROTISING MYOPATHY ASSOCIATED WITH AMIODARONE THERAPY
Author(s) -
CLOUSTON P. D.,
DONNELLY P. E.
Publication year - 1989
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1989.tb00314.x
Subject(s) - medicine , amiodarone , myopathy , muscle biopsy , drug , biopsy , pharmacotherapy , anesthesia , pharmacology , atrial fibrillation
We report a patient who developed an acute painful proximal myopathy associated with the use of amiodarone. The temporal course, the presence of amiodarone related hypothyroidism and neuropathy, as well as the patient's improvement on drug withdrawal were consistent with a drug reaction. Muscle biopsy demonstrated an acute necrotising myopathy. The mechanism for this reaction is unclear.