Premium
RESTORATION OF SPERMATOGENESIS WITH PULSATILE GONADOTROPHIN RELEASING HORMONE THERAPY IN HYPOGONADOTROPHIC HYPOGONADISM OF TRAUMATIC ETIOLOGY
Author(s) -
FOK A. C. K.,
TSAKOK F. H. M.,
SUM C. F.,
CHEAH J. S.
Publication year - 1989
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1989.tb00279.x
Subject(s) - hypogonadotrophic hypogonadism , medicine , pulsatile flow , azoospermia , etiology , hypogonadotropic hypogonadism , spermatogenesis , gynecology , endocrinology , hormone , infertility , pregnancy , biology , genetics
Head trauma is one of the rarest reported causes of hypogonadotrophic hypogonadism and treatment of this condition with pulsatile gonadotrophin releasing hormone (GnRH) has not been previously described. A 36‐year‐old man with azoospermia from hypogonadotrophic hypogonadism following head trauma was given pulsatile GnRH therapy. 10 μg of GnRH was administered every 90 minutes through a subcutaneous catheter in the abdominal wall. After 15 months, the ejaculate contained 34 × 10 6 spermatozoa/ml of semen. Prolonged pulsatile GnRH therapy can restore gonadal function in males with hypogonadotrophic hypogonadism of traumatic etiology. Our experience adds to the growing spectrum of hypothalamic disorders causing hypogonadism that is amenable to treatment by this method.