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VERY HIGH DOSE INTRAVENOUS GAMMAGLOBULIN IN THROMBOCYTOPENIA OF PREGNANCY
Author(s) -
GIBSON JOHN,
LAIRD PAUL P.,
CHILD ANDREW,
HARRIS JOHN,
JOSHUA DOUGLAS E.,
KRONENBERG HARRY
Publication year - 1989
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1989.tb00229.x
Subject(s) - medicine , splenectomy , pregnancy , gamma globulin , adverse effect , platelet , thrombocytopenic purpura , surgery , purpura (gastropod) , anesthesia , antibody , spleen , immunology , ecology , genetics , biology
A 22‐year‐old woman with severe idiopathic thrombocytopenic purpura, complicating pregnancy, was unresponsive to high‐dose corticosteroids and three separate infusions of high‐dose intravenous immunoglobulin using the conventional schedule of 400 mg/kg/d for five days. A dramatic albeit transient, elevation of her platelet count followed a six day course of very high dose immunoglobulin (1000 mg/kg/d) thus allowing elective lower segment cesarean section to be performed without complications and with the delivery of a live, female infant. Two months later a further course of very high dose gammaglobulin was again effective in raising the patient's platelet count prior to elective splenectomy. No adverse reactions were seen to either infusion.