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PROTEIN‐LOSING ENTEROPATHY IN SYSTEMIC LUPUS ERYTHEMATOSUS
Author(s) -
EDMUNDS S. E. J.,
GANJU V.,
BEVERIDGE B. R.,
FRENCH M. A.,
QUINLAN M. F.
Publication year - 1988
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1988.tb01649.x
Subject(s) - anasarca , protein losing enteropathy , medicine , enteropathy , prednisolone , immunology , antibody , complication , systemic lupus erythematosus , gastroenterology , disease
Two patients with systemic lupus erythematosus (SLE) presented with anasarca, pleural effusions and severe hypoalbuminema, Both were demonstrated to have protein‐losing enteropathy, a rare complication of SLE. Other causes of gastrointestinal protein loss were excluded. There were marked similarities in both cases including circulating ANF with speckled staining, anti‐(U1)RNP antibodies and low serum complement levels. Complete remission was achieved in both with prednisolone. Anti‐(U1)RNP may be a marker for a subset of SLE in which protein‐losing enteropathy is a major manifestation.