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THE EFFICACY OF NEDOCROMIL SODIUM (TILADE®) IN ASTHMA
Author(s) -
RUFFIN R. E.,
RUBINFELD A. R.,
ALPERS J. H.,
CZARNY D.,
PAIN M. C. F.,
BOWES G.
Publication year - 1987
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1987.tb01255.x
Subject(s) - nedocromil sodium , medicine , nedocromil , placebo , asthma , bronchodilator , anesthesia , alternative medicine , pathology
Nedocromil sodium is a new antiasthmatic drug with properties similar to sodium cromoglycate. We examined the efficacy of nedocromil sodium compared to placebo in 71 asthmatic patients in a three‐centre double‐blind parallel group study over 12 weeks. During the study the patients' maintenance inhaled corticosteroids were progressively withdrawn. Nedocromil sodium had an advantage over placebo in the number of withdrawals related to uncontrolled asthma, 14 and 24 respectively ( p = 0.03). Changes in symptom scores, peak flow rates and bronchodilator use favoured nedocromil sodium occasionally during the study. The unusual taste of the active drug was reported frequently. Nedocromil sodium is more efficacious than placebo in asthma maintenance, but does not replace inhaled corticosteroids.