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DECREASED INCIDENCE OF ADVERSE INFUSION REACTIONS IN HYPOGAMMAGLOBULINEMIC CHILDREN RECEIVING LOW pH INTRAVENOUS IMMUNOGLOBULIN
Author(s) -
ROBERTON D. M.,
HOSKING C. S.,
EFTHlMlOU H.,
WRIGHT S.,
UPTON H.,
COLGAN T.,
HARTMAN L.,
SCHIFF P.
Publication year - 1987
Publication title -
australian and new zealand journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 0004-8291
DOI - 10.1111/j.1445-5994.1987.tb00106.x
Subject(s) - medicine , incidence (geometry) , intravenous infusions , antibody , adverse effect , crossover study , anesthesia , intravenous use , gastroenterology , immunology , pathology , physics , alternative medicine , optics , placebo
Eighteen patients (ages eight months to 20 years) with disorders of immunoglobulin and antibody production received infusions of two preparations of intravenous immunoglobulin in a blind crossover trial. The incidence and severity of immediate adverse infusion reactions was significantly lower with low pH immunoglobulin; ten patients (56%) experiencing immediate reactions with the standard preparation and only one patient experiencing an immediate reaction with the low pH preparation (p<0.01). Infusion times were significantly less with the low pH preparation p 0.02 and patient tolerance, determined by visual analogue scores, was significantly better than with the standard preparation (p<0.01). However, the incidence of delayed reactions (44%) was the same for both infusions. (Aust NZ J Med 1987; 17: 495–500).